![]() Our results suggest that the use of DFO could be a realistic approach to improve the vascularization of islets during transplantation. ![]() ![]() Finally, the ratio of Bax/Bcl-2 indicated that the apoptosis increased in infected beta-cells whereas treatment with DFO seems to be antiapoptotic. In both treatments, overexpression of VEGF was in a comparable level. Established in 1985, these medals replaced the British Long Service and Good Conduct Medals. In addition, adenoviral infection maintained the viability of cells for all the concentrations used. New Zealand Police Long Service and Good Conduct Medal 2 The Long Service and Good Conduct Medal is a military award recognizing 14 years of exemplary and unblemished service by non-commissioned and other ranks members of the New Zealand Defence Force. One day after treatment, the viability of RINm5F cells was preserved with 10 micromol/L of DFO (103.95 +/- 5.66% toward control n = 4). beta-Cell lines from rat insulinoma (RINm5F) were either infected using an adenovirus encoding the gene of human VEGF 165 or incubated with DFO. The aim of this study was to compare two strategies that are used to overexpress VEGF in beta-cells: (1) gene therapy through adenoviral infection and (2) a pharmacological approach using deferoxamine (DFO). Vascular endothelial growth factor (VEGF) could play a critical role with respect to islet revascularization. Rapid and adequate revascularization of transplanted islets is important for their survival and function during transplantation.
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